Cyclic di-GMP Allosterically Inhibits the CRP-Like Protein (Clp) of Xanthomonas axonopodis pv. citri

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Cyclic di-GMP allosterically inhibits the CRP-like protein (Clp) of Xanthomonas axonopodis pv. citri.

The protein Clp from Xanthomonas axonopodis pv. citri regulates pathogenesis and is a member of the CRP (cyclic AMP receptor protein) superfamily. We show that unlike the DNA-binding activity of other members of this family, the DNA-binding activity of Clp is allosterically inhibited by its effector and that cyclic di-GMP serves as that effector at physiological concentrations.

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ژورنال

عنوان ژورنال: Journal of Bacteriology

سال: 2009

ISSN: 0021-9193,1098-5530

DOI: 10.1128/jb.00845-09